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Is mixing and matching Covishield, Covaxin safe? Study provides BIG update

A Hyderabad-based hospital has conducted a pilot study to determine the safety profile of mixing two COVID-19 vaccines namely Covishield and Covaxin.

The study conducted by AIG Hospitals along with researchers from the Asian Healthcare Foundation showed that mixing Covishield and Covaxin is ‘absolutely safe and there are no adverse effects’ on any of the participants.

A total of 330 healthy volunteers, who were not vaccinated and had no history of the COVID-19 infection, were selected and screened for SARS-CoV-2 antibodies for the study. Out of these, 44 (13%) participants were found to be seronegative, ie, they didn’t have the COVID-related antibodies.

“One of the incidental findings of the study is the seropositivity among our population. 87% of participants who didn’t get vaccinated and never tested positive for COVID-19 had COVID-related antibodies. This means our population might have developed significant antibodies against the COVID-19 because of the huge Delta wave that we endured,” said Dr D Nageshwar Reddy, Chairman, AIG Hospitals.

India, like many other countries, is currently seeing the trend of the third wave fuelled by the Omicron variant. Although the initial data indicates that this wave will be milder than the Delta one with less hospitalization, still a large section of the population might get affected, according to the researchers.

As the Union Government has approved “Prevention” vaccine doses for the healthcare workers, elderly, and the vulnerable population, it is important to find out the cross-immunity generated by mixing of the available vaccines. It is also crucial that the safety profiles are well-established before administrating different vaccines as prevention or booster doses, the researchers added.


44 participants were divided into two four groups.

Group 1: First Dose of Covishield + Second Dose of Covishield

Group 2: First Dose of Covaxin + Second Dose of Covaxin

Group 1 and 2 were the homologous vaccine groups in which same vaccine have been given and relevant antibody titers were checked.

Group 3: First Dose of Covishield + Second Dose of Covaxin

Group 4: First Dose of Covaxin + Second Dose of Covishield

Group 3 and 4 were the heterogeneous vaccine groups in which different vaccines were given and antibody titers were checked. All these 44 participants were followed for 60 days to see if there’re any adverse effects.

The study conclusively found that mixing vaccines are absolutely safe as none of the participants developed any adverse effect. The most important finding of the study was that the Spike-protein neutralizing antibodies found in the mixed vaccine groups were significantly higher than the same-vaccine groups.

“Spike-protein neutralizing antibodies are the ones which kill the virus and reduce the overall infectivity. We found that when the first and second doses are of different vaccines, the Spike-protein antibody response is four times higher compared to two-dose of the same vaccine,” Dr Reddy said.

“This is particularly important when considering the third booster dose. The concept of a booster is to elicit a robust antibody response and help in killing the virus. Mixed doses can certainly boost these Spikeprotein neutralizing antibodies and will enhance the vaccines’ effectiveness even against the Omicron variant,” he added.

The study results show that mixing of Covishield and Covaxin provide a higher antibody response and is safe as well.

The AIG Hospitals has shared the data from the study with the Indian Council for Medical Research (ICMR) to be considered as a reference study while deciding on the “Prevention” doses starting January 10.


48-hr-long weekend lockdown begins across J&K

In a bid to prevent the Covid-19 from spreading, the 64-hour-long weekend lockdown has begun across Jammu and Kashmir on Friday for the third straight week in the Union Territory.

The weekend lockdown was announced by the State Executive Committee (SEC) headed by the Chief Secretary of Jammu and Kashmir following the surge in the Covid-9 cases in Jammu and Kashmir from the past couple of weeks.

All the markets, business establishments and other non-essential services remained closed from the afternoon erewhile public traffic was also off the roads.

However, policemen at different places were seen implementing the Standard Operating Procedures (SOPs) as a number of persons who were found without face masks were fined. The commuters without face masks were also being fined, witnesses said.

The lockdown will continue till Monday morning.

Pertinently, Srinagar, the summer capital of Jammu and Kashmir, has 260 Micro Containment Zones as a number of cases were detected from these localities.

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Five fresh COVID deaths, 4,354 new cases in J&K


Jammu and Kashmir on Friday recorded a single-day spike of 4354 new COVID-19 cases- 2914 in Kashmir and 1440 in Jammu-even as two new deaths were reported in Kashmir and three in Jammu division in the last 24 hours.

The case tally has risen to 424085 while the death toll jumped to 4,647-2,379 in Kashmir and 2,268 in Jammu, officials said.

A total of 374282 patients have recovered from the disease so far including the 5850 in the last 24 hours.

Active cases stand at 45156-11110 in Jammu and 34046 in Kashmir.

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Covid-19: India reports over 2.51 lakh new cases with positivity rate at 15.88%; 627 deaths

India recorded 2,51,209 new cases of the novel coronavirus, along with 627 deaths due to the infection in the past 24 hours. According to the data shared by the Union Health Ministry on Friday (January 28), the country saw 3,47,443 discharges in the last 24 hours, taking the total recovery rate at around 93.60 per cent, and total recoveries data reached 3,80,24,771.

The total active cases of COVID-19 in India have declined to 21,05,611 (5.18 per cent), the ministry data showed today.

The total death toll in the country is now at 4,92,327. The first death due to the COVID pandemic in India was reported in March 2020.

The daily positivity rate is at 15.88 per cent today. According to the Indian Council of Medical Research (ICMR), 72,37,48,555 samples have been tested up to January 27 for COVID-19. Of these, 15,82,307 samples were tested on Thursday.

Also Read: J&K govt orders transfers, postings in civil administration

Meanwhile, according to data released by the health department, Delhi reported 4,291 fresh Covid-19 cases on Thursday and 34 deaths. As a result, the Test Positivity Rate (TPR) in the national capital dropped to 9.56 per cent.

On Wednesday, the national capital reported 7,498 fresh COVID-19 cases and 29 deaths in a day as the positivity rate rose marginally to 10.59 per cent.

In view of the decline in fresh Covid cases, the Delhi Disaster Management Authority decided to lift weekend curfew and the odd-even system of opening non-essential shops in the city besides allowing restaurants, bars, cinema halls and theatres to reopen with 50 per cent capacity.

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Covid-19 Stats

29 Jan 2022, 12:33 PM (GMT)

Coronavirus Stats

40,854,851 Total Cases
493,218 Death Cases
38,346,367 Recovered Cases


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